李赛男

姓名

李赛男

性别

女

出生年月

1985.01

职务（职称）

研究员

学位

理学博士

E-mail

sainan_85@163.com

办公电话

0431-86168379

办公地址

文科实验楼603室

专业

分析化学

研究方向

天然药物化学

荣誉称号

1、吉林省第七批拔尖创新人才三层次；

2、吉林省D类人才；

3、吉林省优青。

主讲课程

学习经历

2015.09-2017.06 中科院长春应用化学研究所，博士后

2012.09-2015.06　 东北师范大学，化学学院，理学博士2009.09-2012.06　 长春师范大学，化学学院，理学硕士

2005.09-2009.06　 长春师范大学，化学学院，理学学士

工作经历

2021.1-至今 　    长春师范大学，中心实验室，研究员2018.09-2021.01　 长春师范大学，中心实验室，副研究员

2015.12-2018.09　 长春师范大学，中心实验室，助理研究员

获奖情况

1、吉林省科技进步一等奖（2019年，第8位）；

2、吉林省自然科学学术成果奖三等奖（2019年，第1位）

学术成果

授权专利：

1、李赛男，刘春明，王恩发，张语迟，时东方.   一种同时制备人身稀有皂苷和油脂不皂化物的方法，发明专利，专利号：ZL201911172798.7，授权时间：2022年1月。

2、李赛男，李彦杰，刘春明，侯万超，时东方，张语迟.   一种中药成分分析超声提取装置，实用新型专利，专利号：ZL202120154905.X，授权时间：2021年12月。

主持主要科研项目（近5年）：

1、吉林省科技厅项目：药用植物升麻中抗阿尔茨海默病微量成分的高效筛选模式及作用机制研究，主持，项目编号：20240602028RC，研究年限：2024-2026（吉林省优青项目）

2、吉林省科技厅项目：四种天然药物中抗癫痫的活性成分筛选及作用机制研究，主持，项目编号：YDZJ202201ZYTS514，研究年限：2022-2024

3、吉林省科技厅项目：药用植物中异黄酮类化合物的分离提取及抗缺血性脑卒中活性评价研究，主持，项目编号：20170520038JH，研究年限：2017-2019

发表学术论文（近5年，截至2024年5月）：

1. Qiang   Liu, Siyuan Zhuang, Sainan Li*,   Yuyu Nong, Yutong Zhang, Jiaqi Liang, Yuchi Zhang, Chunming Liu. Rapid   screening, isolation, and activity evaluation of potential xanthine oxidase   inhibitors in Polyporus umbellatus and mechanism of action in the   treatment of gout [J]. Phytochemical Analysis, 2024, 35 (1): 116-134

2.   Wanchao Hou, Zhen Liu, Yuchi Zhang, Sainan Li*, Chunming Liu. In-depth analysis of   the acetylcholinesterase inhibitors of Ganoderma amboinense based   receptor-ligand affinity coupled with complex chromatography [J]. Journal of   Food Composition and Analysis, 2024, 125, 105776

3. Tong   Wu, Wanchao Hou, Sainan Li*,   Chunming Liu, Yuchi Zhang. Integrated analysis and separation of   5-lipoxygenase inhibitors from triterpenes of Poria cocos using bioaffinity   ultrafiltration UPLC-Q-Exactive, molecular docking and target-based multiple   complex networks [J]. Fitoterapia, 2024, 175: 105856.

4.   Siyuan Zhuang, Haocheng Yun, Xu Zhou, Yanjie Li, Sainan Li*, Chunming Liu, Yuchi Zhang. Screening,   isolation, and activity evaluation of potential xanthine oxidase inhibitors   in Poria Cum Radix Pini and mechanism of action in the treatment of gout   disease [J]. Journal of Separation Science, 2024, 47: 2300505.

5. Yuyu   Nong, Xu Zhou, Sainan Li*,   Qiang Liu, Yutong Zhang, Jiaqi Liang, Yuchi Zhang, Chunming Liu. Efficient   and fast screening and separation based on computer-aided screening and   complex chromatography methods for lipoxygenase inhibitors from Ganoderma   lucidum [J]. Phytochemical Analysis, 2024, 35 (3): 599-616.

7.   Haocheng Yun, Zhen Liu, Wanchao Hou, Qiang Liu, Yuyu Nong, Sainan Li*, Chunming Liu.   Rapid screening and isolation of 5-lipoxygenase inhibitors in Inonotus   obliquus and mechanism of action in the treatment of asthma [J]. Journal of   Separation Science, 2024, 47: 2300647.

8.   Wanchao Hou, Huazhou Niu, Zhen Liu, Yuchi Zhang, Sainan Li*, Chunming Liu.   In-depth analysis of the xanthine oxidase inhibitors of Cicer   arietinum L.-based receptor–ligand affinity coupled with complex   chromatography [J]. Phytochemical Analysis, 2023, 34 (8): 997-1008

9. Tong   Wu, Wanchao Hou, Chunming Liu, Sainan   Li*, Yuchi Zhang. Efficient Combination of Complex Chromatography,   Molecular Docking and Enzyme Kinetics for Exploration of Acetylcholinesterase   Inhibitors from Poria cocos [J]. Molecules, 2023, 28, 1228.

10. Sainan Li, Wanchao Hou, Yanjie   Li, Zhen Liu, Haocheng Yun, Qiang Liu, Huazhou Niu, Chunming Liu, Yuchi   Zhang. Modeling and optimization of the protocol of complex chromatography   separation of cyclooxygenase-2 inhibitors from Ganoderma   lucidum spore [J]. Phytochemical Analysis, 2023, 34 (4): 431-442

11. Sainan Li, Yanjie Li,   YingWang, Ruizhe Li, Huazhou Niu, Chunming Liu, Yuchi Zhang.   Ionic-liquid-based ultrasound-assisted extraction combined with   countercurrent chromatography and semipreparative LC for the preparation   ofmonoamine oxidase B inhibitors from Pueraria thomsonii [J]. Journal of   Separation Science, 2022, 45: 1116–1127.

12. Sainan Li, Chunming Liu, Yuchi   Zhang, Rong Tsao. On-line coupling pressurised liquid extraction with   twodimensional counter current chromatography for isolation of natural   acetylcholinesterase inhibitors from Astragalus membranaceus [J].   Phytochemical Analysis, 2021, 32: 640–653.

13. Sainan Li, Chunming Liu, Yuchi   Zhang, Dongfang Shi, Rong Tsao. Application of accelerated solvent extraction   coupled with online two-dimensional countercurrent chromatography for   continuous extraction and separation of bioactive compounds from Citrus limon   peel [J]. Journal of Separation Science, 2020, 43: 3793–3805.

14.   Chunming Liu, Wanchao Hou, Sainan   Li*, Rong Tsao. Extraction and isolation of acetylcholinesterase   inhibitors from Citrus limon peel using an in vitro method [J]. Journal of   Separation Science, 2020, 43: 1531–1543.

15. Sainan Li, Yuchi Zhang,   Dongfang Shi, Wanchao Hou, Jianli Xia, Chunming Liu. Screening and isolation   of cyclooxygenase-2 inhibitors from the stem bark of Phellodendron amurense   Ruprecht by ultrafiltration with liquid chromatography and tandem mass   spectrometry, and complex chromatography [J]. Journal of Separation Science,   2019, 42: 1905–1914.